DrDeanStMart
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Different patterns of metabolism determine the relative anabolic activity of 19-norandrogens.
https://www.ncbi.nlm.nih.gov/pubmed/7626464In the accessory sex organs (e.g. the prostate) testosterone is 5a-reduced to dihydrotestosterone (DHT) which, due to its higher affinity for androgen receptors (AR), amplifies the action of testosterone.
In contrast, when 19-nortestosterone (NT) is 5a-reduced, its affinity for AR decreases, resulting in a decrease in its androgenic potency.
However, their anabolic potency remains unchanged since significant 5~-reduction of the steroids does not occur in the muscle.
In each tissue the magnitude and quality of the response depends upon the enzymatic activity in that tissue, the active intracellular hormones that are generated, and the receptors that are present. Regardless of the hormone that produces the final response it is, none-the-less, designated androgenic or anabolic depending on the tissue
RECEPTOR BINDING AND THE ROLE OF 5aplha-REDUCTASE
Competitive binding studies to rat prostate androgen receptors showed MENT to be most potent in displacing [3H]mibolorone followed by DHT, NT and T.
In the prostate and seminal vesicles, T is enzymatically 5~-reduced to DHT whose binding affinity to AR and bioactivity on the tissues is 3-5 times greater than that of T.
These events lead to a 2-3-fold amplification of T action in these tissues.On the other hand, muscle contains very little or no functional 5a-reductase enzyme.
Hence the response of the muscle reflects the inherent activity of the unmodified testosterone or another metabolite. NT, which has higher affinity for androgen receptors than T, also exhibits a greater myotropic potency.
However, dihydro-NT, the 5~-reduced metabolite of NT, has lower affinity for AR than NT, T and DHT.
These findings suggest that in contrast to T, whose action is amplified in prostate by its conversion to DHT, the potency of NT on the prostate is reduced by its 5~-reduction to dihydro-NT.
If this explanation is correct then a 5~-reductase inhibitor should have strikingly different effects on the actions of T and NT.
Castrated rats were treated with T or NT with or without the 5a-reductase inhibitor, N,N-diethyl-3-oxo-4-aza-5e-androst-l-ene-17fl-carboxamide.
In castrated rats receiving T, this compound inhibited the stimulatory action of T on the prostate as expected but did not affect its action on muscle.
On the other hand, the 5a-reductase inhibitor increased the prostate weights in rats receiving NT without affecting the effect on muscle.
My conclusion
No conclusion is made in the paper toward a mechanism of why an increase in androgenic activity is seen in NT.
My guess is that NT has a greater affinity for the AR than it does for finasteride.
This means less chance of it converting to DHN – meaning greater effect on androgen receptors and more hairloss.Its not that the combination of the two is wrong…….you’re just fcked either way using nandrolone and have genetic susceptibility to androgenic sides……
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"When you feel like giving up, remember why you started in the first place" -
It SHOULD that’s the key word LOL
As you know some people cut corners.
Hot filtration with molecular sieves is the scientific way….But who does that ????????
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"When you feel like giving up, remember why you started in the first place" -
That’s if they use BA in the first place. Anaerobic bacteria can still proliferate in the oil if the BA concentration is too low or the vial wasn’t sealed corrextly
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"When you feel like giving up, remember why you started in the first place" -
Of course your LH and FSH will be low – hCG will do nothing to keep these up. You are shutdown…….
Your E2 is very high at 382 pmol/L but if you are not experiencing sides then it may not need to be treated especially if lipids are good.
Nolvadex will keep estrogen sides from manifesting but will do nothing to lower E2 – you need an AI to help this.
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"When you feel like giving up, remember why you started in the first place" -
I’ve never heard of it causing that and 5mg would be a low dose.
Did you try reseting your diaphragm when you got the hiccups?
Best way is to try drink water from a full cup but from the opposite side to your mouth and concentrate on not letting any of it spill.www.trainedbyjpclothing.com - The most anabolic clothing ever! |
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"When you feel like giving up, remember why you started in the first place" -
Karbolyn is potato starch so its molecular weight is very differed to HBCD so its absoprtion will be much slower and gastric emptying.
For 40g it should be ok but for larger amounts I would choose HBCD.
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"When you feel like giving up, remember why you started in the first place" -
if he’s calling it that I’m honoured lololol
And it can be taken anytime really. It has roughly 36 half life
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"When you feel like giving up, remember why you started in the first place" -
I’m also trialing it in a friend who’s a nurse and another friend who has just finished competing so we’ll have different demographics who will have trialed it 🙂
Exciting times ahead 🙂 🙂 🙂
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"When you feel like giving up, remember why you started in the first place" -
Nothing from what I have read once its dosed low
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"When you feel like giving up, remember why you started in the first place" -
Whoop whoop !!!
I gave it to my Mother the last 2 nights who is a chronically bad sleeper and unfortunately has to take antipsychotics……so she can’t use 5-HTP as she should have more than enough Serotonin in her brain from the SNRIs……..otherwise she’d be bashing everyone she meets the next morning LOL.
However, the 5 other ingredients from the stack put her clean out the other night :)))
This is why we decided to develop it as a stack rather than have all 6 ingredients in the one capsule so different aspects of it can be dropped depending on what’s causing the lack of sleep ;)))
And as I posted on my InstaStory there are no inhibitory products like Phenibut nor anything like Valerian which can depress and cause issues for asthmatics.
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"When you feel like giving up, remember why you started in the first place" -
Luke have you tried a mix of Holy Basil, KSM-66 and Rhodiola?
Will really help with stress but also your adrenals may be a little worn out from the extended diet time which is why you may be up a pound with water retention I’m thinking ??
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"When you feel like giving up, remember why you started in the first place" -
Update on my side guys.
12 weeks now off – 7 weeks into PCT.
48,000 iU hCG total and 300 iu hMG total – Test is now above 8.5 mmol so we can now drop the gonadotropin therapy and start getting the pituitary going again with the SERM clomiphene.
100mg Clomid to start for 2 weeks then bloods to assess LH, FSH, Test and E2.
So my balls didn’t get fried from 7 weeks of hCG – funny that…….#broscience.
Between not monitoring testosterone level to check it is in “range: and not keeping estrogen low during gonadotropin therapy, I’m becoming more convinced of why conventional PCT recommendations are flawed and why so many fail 6 months later……..
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"When you feel like giving up, remember why you started in the first place" -
If health markers are good and the quality of life is better then TRT is possibly the better choice.
After 2 years it will be rough running a PCT – read through my log and you’ll get a better picture.
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"When you feel like giving up, remember why you started in the first place" -
He’s a chemist so unlikely to cut corners.
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"When you feel like giving up, remember why you started in the first place" -
Oils are g2g – don’t know about orals
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"When you feel like giving up, remember why you started in the first place"