[DrDeanStMart]

What’s the reasoning behind increasing dosage?

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[DrDeanStMart]

Nice FD and correct I have been saying this for a long time and hopefully cover it in detail in my book.

To keep it simple – Estrogen keeps hepatic lipase low which will ensure you are not destroying HDL 🙂

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[DrDeanStMart]

Its going to help with methionine re-cycling and managing homocysteine which will have positive benefits on glutathione synthesis and methylation which may enhave mood as it will all feed off then toward neurotransmitter production

However, be mindful that ploughing yourself with B-12 can be a detriment if you don’t have enough methylfolate to support it.

And B-12 injections are old news lol
I developed an under the tongue liposomal spray with Supplement Needs which delivers 1000mcg per 3 pumps which is the same as the 2 ml shots ¬_¬

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"When you feel like giving up, remember why you started in the first place"

[DrDeanStMart]

I use 2 to ensure the ceiling of Leucine is met. You can get away with 1 serving for sure.

But you also need to take into consideration total daily protein intake which I’m using it toward also.

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"When you feel like giving up, remember why you started in the first place"

[DrDeanStMart]

The elevated prolactin is more than likely being driven by the estrogen.

If natural, look at methods to reduce aromatisation and support liver detox of estrogen.

Look into dopamine support like Mucana Puriens (L-DOPA) and Pyridoxine-5-Phosphate to help lower the prolactin

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[DrDeanStMart]

Hopefully I cleared that question during your consult Vaughan with me 😉

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"When you feel like giving up, remember why you started in the first place"

[DrDeanStMart]

First off – Estrogen rebound is a myth…….

Aromatase won’t upregulate in response to an aromatase inhibitor – the “rebound” is because you go back to aromatising at the same rate you were previously prior to using the AI.

Base your Aromasin dosage off bloodwork rather than a basis of the dosage you are using.
You want to try maintain a balanced ratio or T:E for cardiovascular health.

Hypothetically if it comes back 200-250 pmol; start with 12.mg E3D and then retest bloodwork after 2 weeks.
E2 is about £30 to check so its not expensive.
This will give an idea of the aromatisation rate currently.

Also take into consideration that up until week 5 your plasma hormone levels will have not stabilised yet so rate of aromatisation may increase until this point and area of administration of shots will also play an effect.

Theoretically Aromasin due to being a steroidal suicide inhibitor has a stronger affinity for aromatase than Arimidex which is a non competitive inhibitor.
The research in women shows they are closely matched but with exemestane being slightly better.

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"When you feel like giving up, remember why you started in the first place"

[DrDeanStMart]

So you’re not using Test but you are going to use D-Bol…..??

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[DrDeanStMart]

JZ – it shouldn’t to be honest. Look at Adam Dowling (Adamomachy on IG).

You will need to figure out your threshold as it stands to fermentable foods and fibre intake.

But in now way should it prevent you from being a bodybuilder.

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"When you feel like giving up, remember why you started in the first place"

[DrDeanStMart]

Check in yesterday.

JP and myself very happy with the look currently.
Plus this week strength started to pick up again.

Weight dropped to 203.2 so looks like everything has settled again.

So changes for this week are 20c Post and 10c Post Post on training days.

Diet for anyone interested:

Meal 1
40p, 17f – 165g (4-5% fat) Salmon, 1 Whole Egg, 5g Coconut Oil

Meal 2
42p, 42c – 160g Chicken, 200g Sweet Potato

Meal 3
PreWO – 40p, 50c, 3f
47g Whey Isolate (40g Protein from Whey), 75g Gluten Free Oats

Meal 4
Intra WO – 50p, 70c/60c/50c
85g/72g/60g (Legs/Pull/Push) Sustain Intra, 36g MPS Max, 37g PeptoPro, 5g Creatine.

Meal 5
Post WO – 38p, 183c/178c/173c – 240g Prawns, 126g/119g/113g Jasmine Rice, 100g Coco Pops, Unsweetened Almond Milk

Meal 6
Post Post – 40p, 52c – 165g Chicken, 1 whole Egg, 1 Wrap or Pitta, 50g Pineapple, 20g Jam.

Meal 7
Bedtime – 44p, 12c, 10f – 24g Whey Isolate (20g Protein from Whey), 200g Fage 0% Total Fat Free Greek Yoghurt, 20g 90% Lindt Dark Chocolate

 
Rest Day Meals
Meal 1
40p, 12f – 1 whole egg, 165g Salmon (4-5% fat)

Meal 2
33p, 26c, 7f – 200g extra lean beef (4-5% fat content), 125g sweet potato

Meal 3
38p, 32c, 10f – 200g chicken breast, 35g Jasmine Rice, 20g Cashews

Meal 4
40p. 32c, 9f – 47g Whey Protein (40g Protein from Whey), 75g strawberries, 35g Oats, 20g 90% Lindt Dark Chocolate

Meal 5
38p, 21c, 10f – 200g Chicken, 65g Avocado, 4 Rice Cakes

Meal 6
44p, 8c, 10f – 23.5g Whey Isolate (25g Protein from Whey), 200g Fage 0% Total Fat Free Greek Yoghurt, 20g Almond Butter

Change – NPP to 30mg EOD

So we are now 18 weeks in to the bump from TRT and 4 weeks into the NPP addition

225mg Test E
125mg Mast E
20mg Test Prop EOD
30mg NPP EOD

Bloodwork end of this month to see where everything is

I forgot to post the last set of results from January but the addition of 125mg Mast E dropped my E2 from 281 to 130 which was what was to be expected as to act as a potential AI.
Subsequently HDL took a hit (surprise surprise) from what I have been saying on E2 positive efffects on HDL synthesis.
Will assess trend now at next bloods.

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[DrDeanStMart]

The studies are promising when combined with UC-II.

Gelatin would be another cheap source of collagen too.

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"When you feel like giving up, remember why you started in the first place"

[DrDeanStMart]

Read my write up on TUDCA; it may increase the toxicity if taken together…….

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"When you feel like giving up, remember why you started in the first place"

[DrDeanStMart]

Potentially but the research is on the fence as a 5 alpha reductase inhibitor as the mechanism is still unknown as to the active compound which may have an effect

Pharmacological effects of saw palmetto extract in the lower urinary tract
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002402/

Effect of Increasing Doses of Saw Palmetto on Lower Urinary Tract Symptoms: A Randomized Trial
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326341/

Stinging Nettle Root does however have some interesting research as a 5 alpha reductase inhibitor and is the one I prefer if someone was to consider

The histological and histometrical effects of Urtica dioica extract on rat’s prostate hyperplasia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405682/

Proprietary Herbal Extract Downregulates the Gene Expression of IL-1α in HaCaT Cells: Possible Implications Against Nonscarring Alopecia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126931/
HE was prepared from six plants: Urtica Dioica Root Extract, Urtica Urens Leaf Extract, Equisetum Arvense Leaf Extract, Achillea Millefolium Aerial Part Extract, Matricaria Chamomilla Flower Extract and Ceratonia Siliqua Fruit Extract. These plants were bought from Martin Bauer. Dried plants were fine-cut. 40 g of plant mixture was extracted with 500 mL distilled water for 3 hours at 100°C using soxhlet extraction. The extract was filtered through a filter paper into a sterile bottle.
Among the plants used in our formulation Urtica dioica (Ud) is the most widely studied one. Symptomatic benign prostate hyperplasia (BPH) is the best researched indication of this plant which is mainly due to its 5α-R inhibition activity (23, 24, 25). Inhibition of 5α-R precludes the conversion of testosterone to dihydrotestosterone (DHT) high levels of which are associated with BPH (26). The same pathogenesis is also valid for AGA (3,4). Although Ud leaves have traditionally been used for hair loss, confirmatory clinical trials are still lacking (26). In a study performed with a combination of herbal extracts including Ud, the combination was found to increase the proliferation of human dermal papilla cells significantly at concentrations ranging from 1.5% to 4.5% (27). Ud contains β sitosterol which stimulates angiogenesis by increasing vascular endothelial growth factor (VEGF) synthesis and supports new hair growth (28).

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"When you feel like giving up, remember why you started in the first place"

[DrDeanStMart]

Shingles is nothing to be taken lightly – avoid going out in public as its very contagious and dangerous to pregnant women.

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"When you feel like giving up, remember why you started in the first place"

[DrDeanStMart]

5g would be overkill in honesty regardless of how “large” someone was.

Do you think a large individual requires 10 x the amount of an antibiotic when ill because they are “so large” ……

Genetic control of the androgen receptor is more so why people would lower dosage to allow upregulation again and as above to allow physiological range of hormone balance.

Or increase the dosage more……..

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