[DrDeanStMart]

JBS – You can adjust to cruise dose or do as I said before and allow dosage to clear before beginning cruise dose.

Its really your choice but understand there will overlap in dosage between where you are in a supraphysiological range to when you drop into a physiologic.

You have applied nice logic in your plan.

www.trainedbyjpclothing.com - The most anabolic clothing ever! |
www.trainedbyjp-nutrition.com - The highest quality supplements on the market. |

Instagram - @deanstm
Supplement Needs Discount Code - DRDEAN or TRAINEDBYJP
"When you feel like giving up, remember why you started in the first place"

[DrDeanStMart]

It is a stimulant so avoid close to bedtime

No issue with caffeine preworkout as you are normally

www.trainedbyjpclothing.com - The most anabolic clothing ever! |
www.trainedbyjp-nutrition.com - The highest quality supplements on the market. |

Instagram - @deanstm
Supplement Needs Discount Code - DRDEAN or TRAINEDBYJP
"When you feel like giving up, remember why you started in the first place"

[DrDeanStMart]

Its fake what you are using

And I would not be using both Cyp and Prop combined. You will be creating highs and lows due to the overlap of the esters.

Lol at the hCG reducing the test efficiency- sounds like a good salesman

www.trainedbyjpclothing.com - The most anabolic clothing ever! |
www.trainedbyjp-nutrition.com - The highest quality supplements on the market. |

Instagram - @deanstm
Supplement Needs Discount Code - DRDEAN or TRAINEDBYJP
"When you feel like giving up, remember why you started in the first place"

[DrDeanStMart]

Did they do MRI after the synacthen injection ? Looks like they’re looking for something.

If you feel its contributing to the problem its best being honest

www.trainedbyjpclothing.com - The most anabolic clothing ever! |
www.trainedbyjp-nutrition.com - The highest quality supplements on the market. |

Instagram - @deanstm
Supplement Needs Discount Code - DRDEAN or TRAINEDBYJP
"When you feel like giving up, remember why you started in the first place"

[DrDeanStMart]

As Christoph said, and I shared the papers in the highlight on IG if you want to go read.

Beta-3 receptors are the lipolytic receptors; not beta-2.

Beta-2 adrenergic receptors are what cause the shaking/vasodilation when we look at compounds like Albuterol and Clenbuterol (asthmatic medication) as beta adrenergic agonists.
These receptors downregulate with time meaning you shake less.

Will this stop lipolysis – No.

Could the shakes / increased NEAT from shaking, nervous energy burn more calories overall ? Possibly yes.

Is Ketotifen required to keep the beta-3 activity upregulated for lipolysis? No

Is it required for Beta-2 ? Possibly

But it is beta-3 which is lipolytic not beta-2.

I tried to source to experiment with this but its very expensive – its also an anti-overactive bladder medication (LOL)

Beta3-adrenoreceptor agonist mirabegron – a potential antiobesity drug?
https://www.tandfonline.com/doi/full/10.1080/14656566.2016.1233177

Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298351/

Unlock the Thermogenic Potential of Adipose Tissue: Pharmacological Modulation and Implications for Treatment of Diabetes and Obesity
https://www.frontiersin.org/articles/10.3389/fendo.2015.00174/full

www.trainedbyjpclothing.com - The most anabolic clothing ever! |
www.trainedbyjp-nutrition.com - The highest quality supplements on the market. |

Instagram - @deanstm
Supplement Needs Discount Code - DRDEAN or TRAINEDBYJP
"When you feel like giving up, remember why you started in the first place"

[DrDeanStMart]

JBS – monitoring FBG as you increase carbohydrate and not allowing above 5.5 nmol (preferably 5.1 or 5.2)

In theory, once FBG begins to elevate (trend higher) one could employ insulin at that point provided sensitivity was not ruined.

www.trainedbyjpclothing.com - The most anabolic clothing ever! |
www.trainedbyjp-nutrition.com - The highest quality supplements on the market. |

Instagram - @deanstm
Supplement Needs Discount Code - DRDEAN or TRAINEDBYJP
"When you feel like giving up, remember why you started in the first place"

[DrDeanStMart]

Cris – cycle length is really dependent on health. With shorter esters, probably safer to wait 19-21 days for propionate to fully clear before starting hCG.

Jeff – monitor GGT in bloodwork. On average 4-600mg twice per week should bring down to around 20 provided there is no environmental insult using it up.

Jay – sounds like estrogen:test ratio is out if no morning wood. Cialis may help but if the underlying issue is hormonal that would need to be addressed.

Rotties – very hard to say but as it is a local delivery method I can’t see why not. However, skin of scrotum is very delicate so it nay cause irritation.

Stephen – Have a read of the sleep mechanism highlight I have on Instagram and my sleep topic on here. Magnesium will support COMT which does clear dopamine.

Gianculo – local inflammation like eczema, psoriasis can elevate CRP. Other things such as bowel inflammation and gum disease can also raise it.

www.trainedbyjpclothing.com - The most anabolic clothing ever! |
www.trainedbyjp-nutrition.com - The highest quality supplements on the market. |

Instagram - @deanstm
Supplement Needs Discount Code - DRDEAN or TRAINEDBYJP
"When you feel like giving up, remember why you started in the first place"

[DrDeanStMart]

Max – Correct the reported dosage is anywhere from 1,500-3,000 IU 2 times/week – FDA approved for treatment of infertility due to gonadotropin deficiency
So 2000 iu E2d equates to 6000-8000iu weekly dosage.

However, any excess not used is going to be excreted.

In fact, the male pituitary makes alot less than 1500 iu daily….

A single dose of 15 000–30 000 IU of recombinant human LH is comparable to 5000 IU of urinary hCG.
After intramuscular or subcutaneous injection of such doses, the LH concentrations return to baseline concentrations in about 3 days as compared with 6–7 days for hCG.

The 99.9 percentile for LH is 15 IU/l in men.

In normal men, the amount of detectable hCG averaged 0.0089 ug/L (0.08 IU/L) upto 0.16ug/L
In another paper, men less than 60 yr of age (median, 0.04 IU/L = 0.0044 ug/L)

MW IU/L μg/L pmol
hCG 37 500 1 0.11 2.9

Some good reading

Luteinizing hormone and human chorionic gonadotropin: distinguishing unique physiologic roles
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956631/

LH and hCG Action on the Same Receptor Results in Quantitatively and Qualitatively Different Intracellular Signalling
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465272/

Bio-equivalent doses of recombinant HCG and recombinant LH during ovarian stimulation result in similar oestradiol output: a randomized controlled study
https://www.rbmojournal.com/article/S1472-6483(17)30197-9/fulltext

Gonadotropins in doping: pharmacological basis and detection of illicit use
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2439513/

Pulsatile Secretion of Human Chorionic Gonadotropin in Normal Adults
https://www.nejm.org/doi/full/10.1056/NEJM198712313172702?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed

Serum Levels of Human Chorionic Gonadotropin in Nonpregnant Women and Men Are Modulated by Gonadotropin-Releasing Hormone and Sex Steroids
https://academic.oup.com/jcem/article-abstract/64/4/730/2653775/?redirectedFrom=fulltext

Medical treatment of male infertility
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708300/

www.trainedbyjpclothing.com - The most anabolic clothing ever! |
www.trainedbyjp-nutrition.com - The highest quality supplements on the market. |

Instagram - @deanstm
Supplement Needs Discount Code - DRDEAN or TRAINEDBYJP
"When you feel like giving up, remember why you started in the first place"

[DrDeanStMart]

Max – Correct the reported dosage is anywhere from 1,500-3,000 IU 2 times/week – FDA approved for treatment of infertility due to gonadotropin deficiency
So 2000 iu E2d equates to 6000-8000iu weekly dosage.

However, any excess not used is going to be excreted.

In fact, the male pituitary makes alot less than 1500 iu daily….

A single dose of 15 000–30 000 IU of recombinant human LH is comparable to 5000 IU of urinary hCG.
After intramuscular or subcutaneous injection of such doses, the LH concentrations return to baseline concentrations in about 3 days as compared with 6–7 days for hCG.

The 99.9 percentile for LH is 15 IU/l in men.

In normal men, the amount of detectable hCG averaged 0.0089 ug/L (0.08 IU/L) upto 0.16ug/L
In another paper, men less than 60 yr of age (median, 0.04 IU/L = 0.0044 ug/L)

MW IU/L μg/L pmol
hCG 37 500 1 0.11 2.9

Some good reading

Luteinizing hormone and human chorionic gonadotropin: distinguishing unique physiologic roles
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956631/

LH and hCG Action on the Same Receptor Results in Quantitatively and Qualitatively Different Intracellular Signalling
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465272/

Bio-equivalent doses of recombinant HCG and recombinant LH during ovarian stimulation result in similar oestradiol output: a randomized controlled study
https://www.rbmojournal.com/article/S1472-6483(17)30197-9/fulltext

Gonadotropins in doping: pharmacological basis and detection of illicit use
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2439513/

Pulsatile Secretion of Human Chorionic Gonadotropin in Normal Adults
https://www.nejm.org/doi/full/10.1056/NEJM198712313172702?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed

Serum Levels of Human Chorionic Gonadotropin in Nonpregnant Women and Men Are Modulated by Gonadotropin-Releasing Hormone and Sex Steroids
https://academic.oup.com/jcem/article-abstract/64/4/730/2653775/?redirectedFrom=fulltext

Medical treatment of male infertility
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708300/

www.trainedbyjpclothing.com - The most anabolic clothing ever! |
www.trainedbyjp-nutrition.com - The highest quality supplements on the market. |

Instagram - @deanstm
Supplement Needs Discount Code - DRDEAN or TRAINEDBYJP
"When you feel like giving up, remember why you started in the first place"

[DrDeanStMart]

HI Juan,

Nothing has changed since last update in both diet and supplements – Recapped diet below.

Workout day Meal 1 *
40p, 17f – 165g (4-5% fat) Salmon, 1 Whole Egg, 5g Coconut Oil

Workout day Meal 2 *
42p, 42c – 160g Chicken, 200g Sweet Potato

Workout day Meal 3 *
PreWO – 40p, 50c – 47g Whey Isolate (40g Protein from Whey), 65g Jasmine Rice

Workout day Meal 4 *
Intra WO – 50p, 70c/60c/50c
85g/72g/60g (Legs/Pull/Push) Sustain Intra, 36g MPS Max, 37g PeptoPro, 5g Creatine.

Workout day Meal 5*
Post WO – 38p, 183c/178c/173c
240g Prawns, 126g/119g/113g Jasmine Rice, 100g Coco Pops, Unsweetened Almond Milk

Workout day Meal 6
Post Post – 40p, 52c – 165g Chicken, 1 whole Egg, 1 Wrap or Pitta, 50g Pineapple, 20g Jam

Workout day Meal 7
Bedtime – 44p, 12c, 10f – 24g Whey Isolate (20g Protein from Whey), 200g Fage 0% Total Fat Free Greek Yoghurt, 20g 90% Lindt Dark Chocolate

Rest Day Meals
Rest day Meal 1 *
40p, 12f – 1 whole egg, 165g Salmon (4-5% fat)

Rest day Meal 2 *
33p, 26c, 7f – 200g extra lean beef (4-5% fat content), 125g sweet potato

Rest day Meal 3 *
38p, 32c, 10f – 200g chicken breast, 35g Jasmine Rice, 20g Cashews

Rest day Meal 4 *
40p. 32c, 9f – 47g Whey Protein (40g Protein from Whey), 75g strawberries, 35g Oats, 20g 90% Lindt Dark Chocolate

Rest day Meal 5*
38p, 21c, 10f – 200g Chicken, 65g Avocado, 4 Rice Cakes

Rest day Meal 6
44p, 8c, 10f – 23.5g Whey Isolate (25g Protein from Whey), 200g Fage 0% Total Fat Free Greek Yoghurt, 20g Almond Butter

www.trainedbyjpclothing.com - The most anabolic clothing ever! |
www.trainedbyjp-nutrition.com - The highest quality supplements on the market. |

Instagram - @deanstm
Supplement Needs Discount Code - DRDEAN or TRAINEDBYJP
"When you feel like giving up, remember why you started in the first place"

[DrDeanStMart]

I wouldnt say that you wouldnt see a hypertrophy response in muscle tissue as you will be increasing amino acid transport as a consequence.

It will not have the same myotropic response however as activation of the androgen receptor correct.

Correct you will also improve insulin sensitivity and give beta cells some downtime.

The best way to view insulin is as a tool / nutrient driver and utilising this to advantage.

I would not consider insulin usage until you have reached “natural” potential in terms of peak glucose management from max carbohydrate intake – as insulin use will leave you with another tool

www.trainedbyjpclothing.com - The most anabolic clothing ever! |
www.trainedbyjp-nutrition.com - The highest quality supplements on the market. |

Instagram - @deanstm
Supplement Needs Discount Code - DRDEAN or TRAINEDBYJP
"When you feel like giving up, remember why you started in the first place"

[DrDeanStMart]

Nailed it mate ????

www.trainedbyjpclothing.com - The most anabolic clothing ever! |
www.trainedbyjp-nutrition.com - The highest quality supplements on the market. |

Instagram - @deanstm
Supplement Needs Discount Code - DRDEAN or TRAINEDBYJP
"When you feel like giving up, remember why you started in the first place"

[DrDeanStMart]

Potentially…..

8g astragulus AM and PM

This would be 8 caps AstragFlow from Supplement Needs morning and night

www.trainedbyjpclothing.com - The most anabolic clothing ever! |
www.trainedbyjp-nutrition.com - The highest quality supplements on the market. |

Instagram - @deanstm
Supplement Needs Discount Code - DRDEAN or TRAINEDBYJP
"When you feel like giving up, remember why you started in the first place"

[DrDeanStMart]

Medichecks do a private 24hr saliva cortisol test or look at DUTCH test

Thats if your endocrinologist doesn’t investigate

www.trainedbyjpclothing.com - The most anabolic clothing ever! |
www.trainedbyjp-nutrition.com - The highest quality supplements on the market. |

Instagram - @deanstm
Supplement Needs Discount Code - DRDEAN or TRAINEDBYJP
"When you feel like giving up, remember why you started in the first place"

[DrDeanStMart]

Yes androgens can lower cortisol output significantly.

They need to assess your diurnal pattern of cortisol over 24hrs and see how much cortisone to cortisol you are producing

www.trainedbyjpclothing.com - The most anabolic clothing ever! |
www.trainedbyjp-nutrition.com - The highest quality supplements on the market. |

Instagram - @deanstm
Supplement Needs Discount Code - DRDEAN or TRAINEDBYJP
"When you feel like giving up, remember why you started in the first place"