DrDeanStMart
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Zinc is 1:1 in zinc monomethionine.
30mg Zinc monomethionine would be 15mg zinc considering its 1:1.
Molecular weight of Zinc Monomethionine is 213.58 g/mol
Zinc = 65.38 g/mol = 30% w/w
Methionine = 149.208 g/mol – 70% w/wSo 30mg zinc monomethionine will yield 9mg zinc.
RDA is 15mg.And again, there’s a reason for the zinc methionine…..
Can’t be giving away ALLLLLLL the answers to my super secret Sleep Stack
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"When you feel like giving up, remember why you started in the first place" -
What was history of TSH values?
Can’t really comment without knowing what previous values of TSH whether it is hyperthyroidism.
Also need FT3 as high FT4 doesn’t really say much
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"When you feel like giving up, remember why you started in the first place" -
That is not simple acne vulgaris (pimples) or comedones (blocked hair follicle).
Looks like what is classed as severe inflammed acne.
I would consider a dermatologist as above you may need roaccutane if laser/UV therapy doesn’t work.
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"When you feel like giving up, remember why you started in the first place" -
Could Poor bile and lipase production or Electrolyte imbalance or even something else depending on veg/fiber intake as you’ve given no indication to that.
What’s full complete diet – be as exact as possible
supplements etc
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"When you feel like giving up, remember why you started in the first place" -
How can Mg lose a hydrogen….hmmmm
You’re close 😀
Yes it is 14% roughly by molecular weight.
Considering Magnesium Citrate is 11% by weight…..
And there’s a reason for specifically Magnesium Glycinate….. I’ll let you figure that one out too 😀
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"When you feel like giving up, remember why you started in the first place" -
I’ve no experience with seal oil
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"When you feel like giving up, remember why you started in the first place" -
Yesterday I woke up feeling a little rough and throat was scratchy but decided to train.
Chest, Shoulders, Biceps 2
2 sets 5-9, 10-12
Decline Smith Press
High Incline Smith Press (don’t have a machine at work)
Pec Dec
DB Shoulder Press – I do this with a protonated grip and drive straight up to focus on anterior delt only
Close Grip Smith Press
Cable Side Laterals
Superset High Cable Rear Delt / Front Plate Raise – 2 sets of 15 reps each – this is a killer
Single Arm Seated DB Curl
Seated Dual Arm Curl MachineHowever, once I got home after the 2.5 hour drive from work, I was feeling pretty rough – lethargic, dry throat etc.
Went to bed early but woke up rough again so decided to rest – Legs was due today but in this instance its just not worth further stressing body and taking a step back. Hopefully taking today off will allow me to train tomorrow fingers crossed.
Some useful tips on my IG story if you follow me.
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Supplement Needs Discount Code - DRDEAN or TRAINEDBYJP
"When you feel like giving up, remember why you started in the first place" -
Hi Marty,
Those are cooked weights – JP gives uncooked but I always report it back then as cooked as I cook the same way.
Chicken for example loses about 25% weight when cooked so 125g uncooked would be 100g cooked.
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"When you feel like giving up, remember why you started in the first place" -
Molecular mass of Mg = 24.305 g/mol
Molecular mass of Glycine = 75.07 g/mol
Molecular mass of Bisglycinate (2 Glycines) = 150.14 g/molMolecular mass of Magnesium Bisglycinate = 172.42 g/mol (I’ll let you figure out why its 2 amu less).
Homework
What percentage of weight of Magnesium Bisglycinate is Magnesium ?Then from that percentage, how much of 500mg is Magnesium ? ¬_¬
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"When you feel like giving up, remember why you started in the first place" -
I’m assuming you are asking me? ;’)
An anti histamine can help alleviate the response but you still have high histamine.
I explained this in full on my IG as a highlight.
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"When you feel like giving up, remember why you started in the first place" -
Standardised membranaceous root
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"When you feel like giving up, remember why you started in the first place" -
Hugely person dependent but will have an effect on the rate absorption and pharmacokinetics
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"When you feel like giving up, remember why you started in the first place" -
ED dosing as I explained on the MuscleMentors podcast can often be more favourable with regards to the pharmacokinetics of a drug.
Lets take Enanthate for example:
Having an average half life of 6-7 days, once could do biweekly but it would still yield a small interdose peak and trough although not as severe as single frequency. The peaks and troughs will feed into aromatase activity etc.Any compound or ester, ED dosing will ensure completely stable plasma levels as the drug is being administered and absorbed into the system at the same rate every day.
Pharmacokinetics and Pharmacodynamics of Nandrolone Esters in Oil Vehicle: Effects of Ester, Injection Site and Injection Volume
http://jpet.aspetjournals.org/content/281/1/93.longThis study compared the pharmacokinetics and pharmacodynamics of two currently available esters of nandrolone, the decanoate and phenylpropionate, as well as the influence of i.m. injection sites (gluteal vs. deltoid) and injection volumes (4 mlvs. 1 ml).
We analyzed these data using an indirect pharmacodynamic response model, which has demonstrated, for the first time, prominent pharmacological differences between esters differing in only a single carbon in the side-chain, as well as systematic differences attributable to injection site and volume in humans.
The type of ester influenced the absorption profile of nandrolone:
Phenylpropionate ester was best described by a one-compartment absorption model and the
Decanoate ester was best described by a two-compartment absorption model.
**I discussed one compartment models on the MuscleMentors Podcast****The total dose of the phenylpropionate ester is administered into the “fast” compartment characterized by the rapid absorption rate constant.
Only ∼14% of the total dose of the decanoate ester is administered into this “fast” compartment, with the remaining ∼86% of the total dose being administered into the “slow” compartment characterized by a slower absorption rate constant.
In addition, the rate of absorption from the fast compartment was greater for the deltoid muscle than the gluteal muscle.
**Injection site will make a difference to absorption**Variations in side-chain ester chemistry are important in the pharmacokinetics of androgen esters in oil vehicle (Behre et al., 1990).
Experimental studies suggest that absorption rates are predicted by the oil/water partition coefficients (or hydrophobicity) and that the oil vehicle is absorbed more slowly than the androgen ester (Tanaka et al., 1974).
In humans, the very short propionate (three-carbon aliphatic) ester of testosterone has distinctly shorter duration of action than esters with longer (seven- or eight-carbon) side-chains (Nieschlag et al., 1976;Schulte-Beerbuhl and Nieschlag, 1980; Schurmeyer and Nieschlag, 1984;Belkien et al., 1985; Fujioka et al., 1986).
More subtle changes in side-chain ester structure have proven ineffective in altering human clinical pharmacokinetics, because substitution of a linear aliphatic side-chain of seven carbons (enanthate) with either a saturated, cyclized, seven-carbon aliphatic chain (cyclohexanecarboxylate) (Schurmeyer and Nieschlag, 1984) or a linear, aliphatic, eight-carbon chain (cypionate) (Schulte-Beerbuhl and Nieschlag, 1980) resulted in virtually unchanged kinetics.
**However, inter individuality with regard to sterics of the esters may be imporant with how PDE7B cleaves the esters**Wider variation in ester side-chain chemistry to include greater chain length and/or aromatic ring structures is a more effective determinant of ester pharmacokinetics, because nandrolone hexoxyphenylpropionate ester (aromatic ring with 18 carbons) had far better depot properties, with a prolonged and retarded release profile, compared with the decanoate (aliphatic chain with 10 carbons) (Belkien et al., 1985).
**More obvious as longer chain will be more hydrophobic**The present study indicates that a side-chain ester consisting of a 10-carbon aliphatic chain has better depot properties than a nine-carbon chain including an aromatic ring.
**Again aliphatic nature versus sterics on the ester**Because the vehicle (arachis oil) was unchanged during this study and because of the experimental observation that the oil vehicle influences local reaction to the oil injection (Brown et al., 1944), as well as androgen ester pharmacology (Ballard, 1980; Al-Hindawi et al., 1986), the present conclusions may be extrapolated to other vegetable oil injection vehicles only with caution.
Injection technique, including injection site, volume and concentration, as well as the nature of the vehicle, could theoretically be important for androgen ester release rate.
**But also for downstream effects of aromatase interaction following absoprtion; slower absorption or steadier absorption may be favourable**Injection site may be important because of differences in tissue composition (Cockshott et al., 1982) and blood flow (Bederka et al., 1971); indeed, i.m. oil-based injections may more accurately be termed intermuscular (Ballard, 1968) or intralipomatous (Cockshottet al., 1982).
The former reflects the tendency of oil vehicle to distribute along intermuscular fascial planes (Ballard, 1968), whereas the latter depends upon the amount of fat at the injection site (including systematic gender differences) (Moddermanet al., 1983) together with needle geometry and anatomy of the injection depot.
Intralipomatous deposition of injections with a larger vehicle volume may explain the slower release kinetics of nandrolone decanoate in the gluteal region, as well as the differences from the deltoid site, which has a lower fat content.
The higher blood flow in the deltoid, compared with the gluteal, muscle (Evans et al., 1975) may also be important.
Analogous site-dependent differences in absorption rate and physiological effects have been described for a variety of drugs in aqueous solution (Greenblatt and Koch-Weser, 1976).
To our knowledge, there are no previous reports examining the systemic pharmacokinetic and pharmacodynamic effects of injection site and volume for androgen esters in oil vehicle in men.
www.trainedbyjpclothing.com - The most anabolic clothing ever! |
www.trainedbyjp-nutrition.com - The highest quality supplements on the market. |Instagram - @deanstm
Supplement Needs Discount Code - DRDEAN or TRAINEDBYJP
"When you feel like giving up, remember why you started in the first place" -
This is long to explain…..
Lets take Enanthate for example:
Having an average half life of 6-7 days, once could do biweekly but it would still yield a small interdose peak and trough although not as severe as single frequency. The peaks and troughs will feed into aromatase activity etc.Any compound or ester, ED dosing will ensure completely stable plasma levels as the drug is being administered and absorbed into the system at the same rate every day.
Pharmacokinetics and Pharmacodynamics of Nandrolone Esters in Oil Vehicle: Effects of Ester, Injection Site and Injection Volume
http://jpet.aspetjournals.org/content/281/1/93.longThis study compared the pharmacokinetics and pharmacodynamics of two currently available esters of nandrolone, the decanoate and phenylpropionate, as well as the influence of i.m. injection sites (gluteal vs. deltoid) and injection volumes (4 mlvs. 1 ml).
We analyzed these data using an indirect pharmacodynamic response model, which has demonstrated, for the first time, prominent pharmacological differences between esters differing in only a single carbon in the side-chain, as well as systematic differences attributable to injection site and volume in humans.
The type of ester influenced the absorption profile of nandrolone:
Phenylpropionate ester was best described by a one-compartment absorption model and the
Decanoate ester was best described by a two-compartment absorption model.
**I discussed one compartment models on the MuscleMentors Podcast****The total dose of the phenylpropionate ester is administered into the “fast” compartment characterized by the rapid absorption rate constant.
Only ∼14% of the total dose of the decanoate ester is administered into this “fast” compartment, with the remaining ∼86% of the total dose being administered into the “slow” compartment characterized by a slower absorption rate constant.
In addition, the rate of absorption from the fast compartment was greater for the deltoid muscle than the gluteal muscle.
**Injection site will make a difference to absorption**Variations in side-chain ester chemistry are important in the pharmacokinetics of androgen esters in oil vehicle (Behre et al., 1990).
Experimental studies suggest that absorption rates are predicted by the oil/water partition coefficients (or hydrophobicity) and that the oil vehicle is absorbed more slowly than the androgen ester (Tanaka et al., 1974).
In humans, the very short propionate (three-carbon aliphatic) ester of testosterone has distinctly shorter duration of action than esters with longer (seven- or eight-carbon) side-chains (Nieschlag et al., 1976;Schulte-Beerbuhl and Nieschlag, 1980; Schurmeyer and Nieschlag, 1984;Belkien et al., 1985; Fujioka et al., 1986).
More subtle changes in side-chain ester structure have proven ineffective in altering human clinical pharmacokinetics, because substitution of a linear aliphatic side-chain of seven carbons (enanthate) with either a saturated, cyclized, seven-carbon aliphatic chain (cyclohexanecarboxylate) (Schurmeyer and Nieschlag, 1984) or a linear, aliphatic, eight-carbon chain (cypionate) (Schulte-Beerbuhl and Nieschlag, 1980) resulted in virtually unchanged kinetics.
**However, inter individuality with regard to sterics of the esters may be imporant with how PDE7B cleaves the esters**Wider variation in ester side-chain chemistry to include greater chain length and/or aromatic ring structures is a more effective determinant of ester pharmacokinetics, because nandrolone hexoxyphenylpropionate ester (aromatic ring with 18 carbons) had far better depot properties, with a prolonged and retarded release profile, compared with the decanoate (aliphatic chain with 10 carbons) (Belkien et al., 1985).
**More obvious as longer chain will be more hydrophobic**The present study indicates that a side-chain ester consisting of a 10-carbon aliphatic chain has better depot properties than a nine-carbon chain including an aromatic ring.
**Again aliphatic nature versus sterics on the ester**Because the vehicle (arachis oil) was unchanged during this study and because of the experimental observation that the oil vehicle influences local reaction to the oil injection (Brown et al., 1944), as well as androgen ester pharmacology (Ballard, 1980; Al-Hindawi et al., 1986), the present conclusions may be extrapolated to other vegetable oil injection vehicles only with caution.
Injection technique, including injection site, volume and concentration, as well as the nature of the vehicle, could theoretically be important for androgen ester release rate.
**But also for downstream effects of aromatase interaction following absoprtion; slower absorption or steadier absorption may be favourable**Injection site may be important because of differences in tissue composition (Cockshott et al., 1982) and blood flow (Bederka et al., 1971); indeed, i.m. oil-based injections may more accurately be termed intermuscular (Ballard, 1968) or intralipomatous (Cockshottet al., 1982).
The former reflects the tendency of oil vehicle to distribute along intermuscular fascial planes (Ballard, 1968), whereas the latter depends upon the amount of fat at the injection site (including systematic gender differences) (Moddermanet al., 1983) together with needle geometry and anatomy of the injection depot.
Intralipomatous deposition of injections with a larger vehicle volume may explain the slower release kinetics of nandrolone decanoate in the gluteal region, as well as the differences from the deltoid site, which has a lower fat content.
The higher blood flow in the deltoid, compared with the gluteal, muscle (Evans et al., 1975) may also be important.
Analogous site-dependent differences in absorption rate and physiological effects have been described for a variety of drugs in aqueous solution (Greenblatt and Koch-Weser, 1976).
To our knowledge, there are no previous reports examining the systemic pharmacokinetic and pharmacodynamic effects of injection site and volume for androgen esters in oil vehicle in men.
www.trainedbyjpclothing.com - The most anabolic clothing ever! |
www.trainedbyjp-nutrition.com - The highest quality supplements on the market. |Instagram - @deanstm
Supplement Needs Discount Code - DRDEAN or TRAINEDBYJP
"When you feel like giving up, remember why you started in the first place" -
Gillespie – Anti TNF drugs are well known to increase viceral fat storage. Most of the studies look at psoriasis and rheumatic arthritis.
Tumor necrosis factor (TNF) is a proinflammatory cytokine that impairs response to insulin in adipocytes and muscle cells via inhibition of tyrosine kinase activity of the insulin receptor, activation of peroxisome proliferator–activated receptor-δ, and changes in secretion of adipokines.
So high levels of TNF will impair insulin sensitivity – its not necessarily the anti0-TNF drugs which are causing the problem but the underlying condition itself.
I can’t really comment as to why the HGH improved symptoms in regards to Crohn’s which is an autoimmune disease.
It could be transiently due to increase in repair in body although it may have then increased TNF which may be why you have needed to go back to an anti-TNF drug now after running it….
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www.trainedbyjp-nutrition.com - The highest quality supplements on the market. |Instagram - @deanstm
Supplement Needs Discount Code - DRDEAN or TRAINEDBYJP
"When you feel like giving up, remember why you started in the first place"