DrDeanStMart
Forum Replies Created
-
camt say without knowing estradiol
www.trainedbyjpclothing.com - The most anabolic clothing ever! |
www.trainedbyjp-nutrition.com - The highest quality supplements on the market. |Instagram - @deanstm
Supplement Needs Discount Code - DRDEAN or TRAINEDBYJP
"When you feel like giving up, remember why you started in the first place" -
2 would be better for stable levels or even ED micro dose
www.trainedbyjpclothing.com - The most anabolic clothing ever! |
www.trainedbyjp-nutrition.com - The highest quality supplements on the market. |Instagram - @deanstm
Supplement Needs Discount Code - DRDEAN or TRAINEDBYJP
"When you feel like giving up, remember why you started in the first place" -
GLA -> AA precursor
www.trainedbyjpclothing.com - The most anabolic clothing ever! |
www.trainedbyjp-nutrition.com - The highest quality supplements on the market. |Instagram - @deanstm
Supplement Needs Discount Code - DRDEAN or TRAINEDBYJP
"When you feel like giving up, remember why you started in the first place" -
Right tonight’s session at work.
Had to work around my lower back as its been at me since last week.
Even training Legs on Sunday I was praying it would hold up during the session.
Had deep tissue work done before work but Will said my lower back is misaligned so I’ll be seeing Conn on Monday for my monthly neck adjustment so he’ll sort it then. Feels like pressure which runs down into glute.
Will really is a wizard as some of the blockage was in my right external oblique – which was quite nasty to have released :LTonight’s Session was:
Chins – 3 sets. Close Grip, Wide Grip, Underhand. BW
Chest Supported DB Rows – 3 sets ; 25 x 12, 25 x 11, 25 x 10
Cable Pulldown with D-handles 3 sets ; 70 x 8, 50 x 12
Machine Row 3 sets ; 40 x 30, 55 x 12, 55 x 10
Assisted Chin Wide Grip – 42.5 x 17
Wide lat Pulldown – 50 x 17
Assisted Chin Close Grip – 42.5 x 15
Wide Lat Pulldown – 45 x 15Check in tomorrow with JP.
Will post up progress pics as we will be 12 weeks into TRT post PCT.www.trainedbyjpclothing.com - The most anabolic clothing ever! |
www.trainedbyjp-nutrition.com - The highest quality supplements on the market. |Instagram - @deanstm
Supplement Needs Discount Code - DRDEAN or TRAINEDBYJP
"When you feel like giving up, remember why you started in the first place" -
My legs have just about recovered this evening from that session XD
www.trainedbyjpclothing.com - The most anabolic clothing ever! |
www.trainedbyjp-nutrition.com - The highest quality supplements on the market. |Instagram - @deanstm
Supplement Needs Discount Code - DRDEAN or TRAINEDBYJP
"When you feel like giving up, remember why you started in the first place" -
Store in fridge yes.
You never gave the concentation of vial? I’m assuming 5000 iu vial?
1ml into 5000 iu would be
0.1 ml is 500 iu so
0.4ml would be 2000 iu2.5ml into 5000 iu would be
0.1ml is 200 iu so
1ml would be 2000 iuSo 1ml of 2.5ml in 5000 iu is 2000 iu correct
www.trainedbyjpclothing.com - The most anabolic clothing ever! |
www.trainedbyjp-nutrition.com - The highest quality supplements on the market. |Instagram - @deanstm
Supplement Needs Discount Code - DRDEAN or TRAINEDBYJP
"When you feel like giving up, remember why you started in the first place" -
Low chloride and low bicarbonate….
I’d retest pretty soon to be sure its not a hydration/electrolyte loss issue.
Both combined with high Creatinine would not be something to ignore.
www.trainedbyjpclothing.com - The most anabolic clothing ever! |
www.trainedbyjp-nutrition.com - The highest quality supplements on the market. |Instagram - @deanstm
Supplement Needs Discount Code - DRDEAN or TRAINEDBYJP
"When you feel like giving up, remember why you started in the first place" -
The carrier will have a coefficient partition with respect to being miscible into the blood – which may be fasted than the compound, so the carrier oil may enter systemic circulation quicker than the dissolved compound leaving the compound to irritate the tissue.
The compound will have a coefficient partition of its own but in respect of tissue-blood which has more to do with how the compound can pass through lipid bilayer membrane.
Transference via osmosis and enzymatic transportation???
I think you’re confused with Diffusion.
IM depot drugs diffuse from the site of injection, 17B ester is acted on by PDE which breaks that off to remove ester and leave parent molecule.
Once parent molecule passes into blood then it may interact with a plasma binding protein (SHBG) for transport.And the first study…. with regards to being aqueous solutions…..was to show the effect the carrier has on the pharmacokinetics.
www.trainedbyjpclothing.com - The most anabolic clothing ever! |
www.trainedbyjp-nutrition.com - The highest quality supplements on the market. |Instagram - @deanstm
Supplement Needs Discount Code - DRDEAN or TRAINEDBYJP
"When you feel like giving up, remember why you started in the first place" -
Haha thanks John.
Neck is doing very well. Neck traction is a daily habit now but I’m at the stage whereby I’m placing it on top of a book otherwise my head touches the ground so as to provide better traction.
I’d imagine a lot of general population on top of bodybuilders have issues with forward neck posture etc.
With my neck I had no mobility to the right due to how forward it was and obviously that was then putting severe pressure and tension down my spine.www.trainedbyjpclothing.com - The most anabolic clothing ever! |
www.trainedbyjp-nutrition.com - The highest quality supplements on the market. |Instagram - @deanstm
Supplement Needs Discount Code - DRDEAN or TRAINEDBYJP
"When you feel like giving up, remember why you started in the first place" -
Mark – just follow maintenance and light activity like walking will help with the healing
www.trainedbyjpclothing.com - The most anabolic clothing ever! |
www.trainedbyjp-nutrition.com - The highest quality supplements on the market. |Instagram - @deanstm
Supplement Needs Discount Code - DRDEAN or TRAINEDBYJP
"When you feel like giving up, remember why you started in the first place" -
Mag stirrers won’t remove heavy metals from a solution – I worked with Lead Dioxide alot during my PhD which required its removal from solution and my product but I’m not telling people how you can easily remove heavy metals.
Also, the carrier oil does make a difference !
This is where UGLs are amateurs at best……Different oils will have different coefiicient partitions – If you don’t know what a coefficient partition is then you shouldn’t be making up steroid solutions….
Remember the oil is organic, your blood is aqueous.
You want the compound to be easier to miscible from organic oil depot in tissue to blood.
So not only do you have to take ester into account, you also need to take into account the carrier with regards to the pharmacokinetics.
MCT miscibility may be faster than the steroid itself in which it is dissolved leading to crystallisation at the site and ultimately PIP.Effect of the injection solvent on steroid activity.
https://www.ncbi.nlm.nih.gov/m/pubmed/3817442/?fbclid=IwAR26FX9rREL6DuNE5xUkggzYJF-3_p5dQ03cxCUeZyxwTDUxyTYGm5sxSuUOctanol-Water Partition Coefficients of Simple Organic Molecules
https://www.nist.gov/sites/default/files/documents/srd/jpcrd367.pdfPartition coefficient
https://www.sciencedirect.com/topics/medicine-and-dentistry/partition-coefficientLogP—Making Sense of the Value
https://www.acdlabs.com/download/app/physchem/making_sense.pdfIntramuscular rate of disappearance of oily vehicles in rabbits investigated by gamma-scintigraphy
https://www.sciencedirect.com/science/article/pii/S0378517398001215?via%3Dihub&fbclid=IwAR0jY4sNlcxXYUnuXxVZcl97j6WDZuPRfj1lq1b4d-lDtE7l1Rw2d3airlg
Comparison of pharmacodynamics of Sesame Oil versus MCTCritical Factors Influencing the In Vivo Performance of Long-acting Lipophilic Solutions—Impact on In Vitro Release Method Design
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782087/
Table III
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782087/table/Tab3/?fbclid=IwAR12-NMSkXY9Bw8OgNU676QIJxm8Cqu9jxVnS2hjR1nV_aLbra3I_xJWNesMean HALF-lives (t½, n = 6) for the Clearance of Oil Vehicles after i.m. or s.c. Administration to pigs (29)
Oil vehicle t1/2 in days
Fractionated coconut oil 14
Castor oil 20
Isopropyl myristate 20
Sesame oil 23The rationale for investigating the rate of disappearance of oily vehicles from the injection site is to determine the influence of the vehicle on the duration of action of parenteral depot formulations.
Probably, the partition coefficient of the drug compound between the oily vehicle and the tissue fluid determines the release mechanism.
Extremely lipophilic drugs (for instance decanoate esters) possessing very high affinities for the oily phase, are probably released concurrently with disappearance of the vehicle.
Less lipophilic drug compounds may, by simple partition, be released from the oil phase to the tissue fluid prior to disappearance of the oil.Added bonus paper
Pharmacokinetics and Pharmacodynamics of Nandrolone Esters in Oil Vehicle: Effects of Ester, Injection Site and Injection Volume
http://jpet.aspetjournals.org/content/jpet/281/1/93.full.pdf?fbclid=IwAR2sgtqgSo8xPSch7C3Pd5F1s0io_GSeuWJ2CUVBfKOaiMYdo788xnaHJ2w
The present study demonstrates that, in addition to the chemistry of the side-chain ester, both injection site and volume can systematically influence blood nandrolone levels after i.m. injection of nandrolone esters in an oil vehicle formulation.www.trainedbyjpclothing.com - The most anabolic clothing ever! |
www.trainedbyjp-nutrition.com - The highest quality supplements on the market. |Instagram - @deanstm
Supplement Needs Discount Code - DRDEAN or TRAINEDBYJP
"When you feel like giving up, remember why you started in the first place" -
With both 19-nor derivatices involved it could be prolactin driven.
Hard to say without bloodwork
www.trainedbyjpclothing.com - The most anabolic clothing ever! |
www.trainedbyjp-nutrition.com - The highest quality supplements on the market. |Instagram - @deanstm
Supplement Needs Discount Code - DRDEAN or TRAINEDBYJP
"When you feel like giving up, remember why you started in the first place" -
As above, once prepared sterile and kept sealed with a new needle attached to syringe.
Change needle again before injection if concerned about sterility.
www.trainedbyjpclothing.com - The most anabolic clothing ever! |
www.trainedbyjp-nutrition.com - The highest quality supplements on the market. |Instagram - @deanstm
Supplement Needs Discount Code - DRDEAN or TRAINEDBYJP
"When you feel like giving up, remember why you started in the first place" -
Need FSH and LH to fully assess HPTA.
www.trainedbyjpclothing.com - The most anabolic clothing ever! |
www.trainedbyjp-nutrition.com - The highest quality supplements on the market. |Instagram - @deanstm
Supplement Needs Discount Code - DRDEAN or TRAINEDBYJP
"When you feel like giving up, remember why you started in the first place" -
I had full gland removal done in Medimel in Poland in 2013.
You really need a skilled surgeon and Dr Clark is THE best in the world – absolutely no doubt there.
Private clinic who only treats one patient at a time and overnight stay with private nurse.
Cost was 1800 euro.She removed the full gland and done liposculpture whereby she pushes fat into area to prevent inversion.
The only risk she highlighted was possible nipple loss in less than 1% of cases.You should invest in a Macom Compression vest to help healing.
Due to the stitches around nipple and drain puncture you shouldn’t raise arms overhead for 2 weeks minimum.
Its quite a brutal surgery in terms of trauma/pain but the rest and recovery is very worth it.
I was 6 weeks total before training upper body.
Week 3 I began training light legs.No evidence at all of any scars etc.
www.trainedbyjpclothing.com - The most anabolic clothing ever! |
www.trainedbyjp-nutrition.com - The highest quality supplements on the market. |Instagram - @deanstm
Supplement Needs Discount Code - DRDEAN or TRAINEDBYJP
"When you feel like giving up, remember why you started in the first place"