[DrDeanStMart]

Update guys

Thursday began the start of the hCG side of things – 2000 IU E2D for 20 days along with 25mg Aromasin and 20mg Nolvadex.

Like I said I will get bloods done immediately after the 20 days and assess where testosterone is and make the next decision based off that.

However, this morning my mood was vastly improved and no gloomy feeling waking up. I’ve been really struggling with daily motivation but it’s a nasty part of the process.

Trained legs on Thursday with Morgan and got ruined…….my recovery is pretty low at the moment so I’m finding I’m sore for 3-4 days afterwards.

If you saw my IG on Saturday (yesterday), you would have gotten introduced to my brother Ashley and the unfortunate crushing of his baby finger under a barbell on Friday when he couldn’t get it off his back squatting :/
Yesterday he said I’m going training with you and just do one sided presses……then the bandages came off his finger when we got home and I had to take him back to A & E for it to be re bandaged.

I should get him on a Live feed someday again as he is studying a sports science degree in sports coaching and management.
He’s one funny fcker…….LOL

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[DrDeanStMart]

Agreed 😀 😀

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[DrDeanStMart]

Hi Fabian,

That is a very broad and quite complex question !

So lets look at thyroid hormone metabolism:

The thyroid hormones T4 and T3 are created from a protein called thyroglobulin which is made up of tyrosine and found in follicular cells.

Thyroid Peroxidase is an enzyme within the follicles which forms the precursors to T3 and T4 known as monoiodotyrosine (MIT), and diiodotyrosine (DIT).
These are formed when the tyrosine units on thyroglobulin bind to Iodine.

Thyroid Stimulating Hormone (TSH) is released by the pitiutary gland but is controlled by Thyrotropin-releasing hormone (TRH) in the hypothalmus.

When TSH stimulates the follicular cells in the thyroid, the iodinated tyrosines of thyroglobulin get removed to yield T4 and T3 for secretion by the gland which is about 90% T4 and 10% T3.

Deiodinase enzymes then in other peripheral tissues remove iodine to convert T4 to T3.

When thyroid hormones are high, TSH production is suppressed.
This same negative feedback also occurs when TSH is high.
TSH is what ultimately regulates our thyroid metabolism in what amounts of T4 and T3 are produced by the body.

After secretion from the thyroid, only a very small proportion of the thyroid hormones travel freely in the blood.
Most are bound to thyroxine-binding globulin (TBG) and other protein binding transporter.

Now lets looks at a contest prep scenario:

Calories are being reduced to lower bodyfat.
Lowering bodyfat ultimately leads to a lowering in Leptin signalling/production which is why carb refeeds are often introduced.

Leptin has now been shown to be important in having a regulatory effect on TSH which ultimately feeds into transforming T4 to T3. Low Leptin being associated to a decrease in TSH activity.
The role of leptin in the regulation of TSH secretion in the fed state: in vivo and in vitro studies
T M Ortiga-Carvalho, K J Oliveira, B A Soares
https://pdfs.semanticscholar.org/a3f1/0a6fde95169efc42e245faa582ea44cf57b9.pdf

Another thing is the gut is one of the main storage areas for T4 and T3 which very few know about.
Gut bacteria in the GI tract produce and ezyme which assists in converting about 20 % T4 to T3 in the GI tract in the forms of T3 sulfate (T3S) and triidothyroacetic acid (T3AC)

Dysbiosis and inflammation in the gut can lead to significatnly lower conversion as well as inflammation raising cortisol which would increase the conversion of T3 to RT3.

Increases in Androgens/Estogren can also influence the amount of TBG (thyroid binding globulin) made.

So we have someone on reduced calories (lowered leptin), possible gut inflammation from the off season or general lifestyle (dysbiosis), stressed (increased cortisol) and taking in excess androgens/converting estrogen (high TBG likely)……..

So you can see this all having an impact on TSH production –
You would be monitoring bloods taking at start of prep and 6 weeks later and taking note……

If TSH was high, T4 was slightly low but T3 conversion was low-normal then one could increase the pool of available T4 by supplementing. The body would do the conversion itself naturally and help lower stress on the pituitary and reduce TSH.

If TSH was normal, T4 was normal and T3 low then it could be TBG causing a delivery issue or a conversion issue (iodine, selenium deficiency, poor conversion in gut etc) or loss to RT3.

If TSH was low and consequently T4 was low, then it could be an issue with HPTA signalling.

This post is almost an article in itself !!!

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[DrDeanStMart]

Hi Emil,

I would start very low with maybe 0.2-0.4 ml and build up to the 450mg / 5ml most of which are.

If there are any roadblocks in your glutathione recycling you will get some nasty headaches from the rapid detox.

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[DrDeanStMart]

Hi Matthew,
What was the exact PCT?

Successful hCG therapy should bring testosterone levels back to a “normal” level but the standard POWER PCT duration may not be enough (I’ve provided plenty of research papers to read).

When were bloods taken after the PCT?

My natural levels were very poor also in my early 20s and I can empathize with how low testosterone can effect someone.

I would get fertility checked first before making the decision to blast and cruise.

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[DrDeanStMart]

Or buy a pair of plate loadable dumbells.

I got a pair for 60 euro but you’ll need someone to hand them to you due to the collars.

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[DrDeanStMart]

It will say “processed with alkali” on the ingredients

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[DrDeanStMart]

Kane I don’t think so.

I posted a while back a literature review on Berberine – search and you’ll find it.

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[DrDeanStMart]

I would get bloods done Stuart than blindly supplement.
Could be a wide variety of root causes.

Have Full RBC, female hormone panel, thyroid hormone panel, serum folate and B12 levels along with 25-OH (vitamin D3) checked. After that its much easier to figure out the problem.

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[DrDeanStMart]

Depends on what your needs are personally – whether soluble or insoluble fibre is needed.

Psyllium husk is good for providing a bulk mass to help food move along provided water intake is good.
Remember soluble fibre absorbs water.

Insoluble fibre passes through your digestive tract pretty intact.
It can help by a prebiotic also.

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[DrDeanStMart]

Fran,

You could try Cabergoline as it is a dopamine agonist so it will free up more dopamine in your brain.

However, remember if COMT can’t clear the dopamine then its just going to build up even more and give you worse anxiety !

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[DrDeanStMart]

Mort,
Probably because no one has studied these links or made much thought because…..”Bro Science” \m/ \m/

50mg P-5-P is more than sufficient.
Start with 50mg 5-HTP and go as high as 250-300mg.

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[DrDeanStMart]

Joseph,

Quite a big difference.

How an element is chelated makes a huge difference.
Mg Glycinate will be cleaved to yield Mg and Glycine, the Glycine feeds into you GABA cycle to calm you down.

Now if you took 2g of Mg Oxide, it would enter the intestine and relax the intestinal muscles giving you a laxative effect.
2g of Mg Sulfate (Epsom Salt) and you will be needing a toilet quickly…..LOL

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[DrDeanStMart]

Super K by Life Extension – has both MK-4 and MK-7

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[DrDeanStMart]

As above androgens are what control hair growth.

Androgens and hair growth.
https://www.ncbi.nlm.nih.gov/pubmed/18844710

And another one on if you aren’t so lucky to have beard gainzzz

Differences in testosterone metabolism by beard and scalp hair follicle dermal papilla cells.
https://www.ncbi.nlm.nih.gov/pubmed/8287580

Interesting paper which showed a difference of coeliacs having greater hair density but slower growth.
Relationship between plasma testosterone and dihydrotestosterone concentrations and male facial hair growth.
https://www.ncbi.nlm.nih.gov/pubmed/7126460

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