DrDeanStMart
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Definitely is annoying Cameron but glad you are being proactive !
Rotties, I absolutely agree that you could get by with a few weeks of no injections after using 600-750mg with regard to the drug clearance.
There wouldn’t be any point to adding in hCG for only the cruise. It would be better taken from the start of a cycle if fertility was known and sperm was being produced as the hCG would then just be tiding over spermatogensis and keeping leydig cells stimulated until you came off fully.If we simplify the half life to 7 days then by Week 6 most of the compound is fully metabolised (For 600mg, by start week 7 there’s approx 9 mg still in system IN THEROY) so you wouldn’t see this tie over if you are taking bloods 6 weeks after last pin and 2-3 shots into your cruise with sust.
Remember the drug clearance will be based on ester cleavage by the body and how well the drug partitions in fat combined with CYP 450 metabolism in the liver.
I’ll be getting bloods done Thursday which will be 4 weeks after last shot so I will be able to give an indication towards the actual pharmacokinetics in my own body and can give an idea of how 200mg metabolised over 4 weeks.
But it’s definitely nearing rock bottom based on how I’m feeling at the moment which is pretty shit !
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"When you feel like giving up, remember why you started in the first place" -
Thanks guys for the welcome back 🙂
I forgot my Denneroll Cervical Orthotic when travelling to Dublin on Friday so I’ve been taking it easy with training.
Waiting on a call back from Conn as I’ve now missed 5 days in a row with the orthotic and was making good progress (you might have seen me lie on it on my IG story) with my neck now almost back to touching the ground.
So……for the last 4 years Glenn my physio has been fighting to keep breaking down hard tissue in my rhomboids and scapula. After 4 weeks off work and the rest from intense training he was able to break down the tissue once and for all just before we went away on honeymoon.
I visited Glenn Friday when I got back to Dublin to help my neck and lower back and everything felt great afterward……..
2 days back to work and 2×12 hour shifts…….
I left work yesterday evening to see him with bad tightness in my scapula, rhomboids and upper traps……..so the extended break from work revealed what has been “injuring” me all these years……..holding my hands out in front at my keyboard combined with intense training…..After discussing with Glenn, even though I would only spend 9 out of the 12 hours seated and at my desk, I need to make a conscious effort to make use of my adjustable height desk to standing desk for a few hours per shift and ensure to try stretch every couple hours. Even lightly holding a correct 90 degree seated posture with your hands hovering at the mouse and keyboard over a 12 hour shift builds some amount of tension which you probably wouldn’t notice if you are training as everything would be “tense” to a certain degree.
But with the extended rest and break from work, its helped show me how “injuring’ my job can be so will be definitely be able to address this going forward.
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"When you feel like giving up, remember why you started in the first place" -
Your test is low.
Hypothetically, you can try running PCT again in hopes of increasing HPTA output or do the obvious and raise it directly…www.trainedbyjpclothing.com - The most anabolic clothing ever! |
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"When you feel like giving up, remember why you started in the first place" -
Hi Carl, you’re test is fairly similar; low test and low E2 which is more than likely poor aromatisation of your low level of testosterone.
Cortisol is a little high but TSH and SHBG are good so I wouldn’t be concerned.
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"When you feel like giving up, remember why you started in the first place" -
See how libido is affected after dropping the caber.
It could well have been that your prolactin was too low.
Again low prolactin in males is still pretty misunderstood and unknown.www.trainedbyjpclothing.com - The most anabolic clothing ever! |
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"When you feel like giving up, remember why you started in the first place" -
IF it is an androgen issue, EQ will only make this worse as it will stress COMT even more.
What were you taking previous to going in to that cycle?
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"When you feel like giving up, remember why you started in the first place" -
Sure
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"When you feel like giving up, remember why you started in the first place" -
It’s a side effect of the Clomid. Take it before bed to help reduce some of the mood issues. Clomid is a synthetic estrogen so you will be susceptible to it.
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"When you feel like giving up, remember why you started in the first place" -
Remove the androgen as that would slow down COMT.
Take your morning HR for a week. But if feeling anxious when waking up is a clear sign CNS is stressed.
I would take a full week off and rest completely and try de stress.
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"When you feel like giving up, remember why you started in the first place" -
Right I guess it’s time I updated this 🙂
What an amazing honeymoon – the cruise was unbelievable; I’m sure a lot of you saw on IG 🙂
We landed Monday morning at 11 a.m after an overnight flight from Miami.
10mg Melatonin soon as we got on the flight and lights out…..stayed up until 11 p.m Monday and no jet lag Tuesday.As mentioned, we are looking to start a family now after getting married.
In this case you have 2 choices depending on your fertility status.
1. You are producing zero sperm – in this case you’ve no choice but to come off any exogenous hormones and try re-establish own natural production by re-starting HPTA and getting sertoli cells to produce sperm again.2. You are producing sperm but counts are low (less than 15 million) – in this case you can try remain on TRT and “boost” LH/FSH to try increase sperm count; your sertoli cells are still producing sperm so exogenous sources are not inhibiting production.
I fall into the 2 but have opted to come off and try get everything running naturally.
It’s 3 years since last Power PCT and my levels have always been naturally low – 8 mmol since 22.3.5 weeks since last shot and mood/energy this week is declining (tired/sleepy/unmotivated) but expected. Had an awful migraine Thursday night just as I began training legs and had to abandon ship as it felt as if my head was going to explode so had to go home and just straight to bed and sleep.
Will get bloods done this week and see where markers are at……
However, based off the pharmacokinetics, 9th April will be the start of hCG as all exogenous will be fully cleared…..that’s right 6.5 weeks after the last shot is when levels in theory will be fully bottomed out at 0 for 200mg……not the 14 days after last shot nonsense that is often advocated…..The protocol I will use will be a modified version of Power PCT using hCG and hMG with SERM treatment.
I have RedCon1 Boomstick to implement later on for its DHEA and other nice ingredients once I’m happy HPTA is functioning.I see some people are really looking for hMG. I can’t discuss sources/names but maybe an all day chemist might be able to help with their knowledge…..and DO NOT DM me, that’s as much of a clue as I’m giving and you will be ignored !!
Yes it is expensive at approx 35 euro per 75 IU but looking at the studies it is well worth it if boosting sperm count is the objective.I’ve posted this before, but below are the all the articles related to hCG/hMG therapies in hypogonadism males and spermatogenesis.
IN THEORY, the best protocol is 1500-2000 I.U hCG combined with 75 I.U hMG in conjuction with an Aromatase Inhibitor followed by SERM treatment.
https://www.ncbi.nlm.nih.gov/pubmed/6430049
https://www.ncbi.nlm.nih.gov/pubmed/3142911
https://www.ncbi.nlm.nih.gov/pubmed/3928676
https://www.ncbi.nlm.nih.gov/pubmed/27475410
https://www.ncbi.nlm.nih.gov/pubmed/19838805
Excellent article on Spermatogenesis – use Google Chrome to translate from French.
https://www.sciencedirect.com/science/article/pii/S1297958916301588?via%3Dihubhttps://www.ncbi.nlm.nih.gov/pubmed/9813187
Normally,
GnRH (Gonadotropin-releasing hormone) acts on the pituitary gland, which will secrete FSH and LH gonadotropins that are released into the bloodstream.
LH acts on Leydig cells to stimulate testosterone production. Part of the testosterone will act intratesticularly on Sertoli cells to initiate spermatogenesis.
FSH works together with intratesticular testosterone in Sertoli cells of seminiferous tubules to enhance spermatogenesis.Increases in circulating testosterone will inhibit the secretion of GnRH and gonadotropins (when you take exogenous testosterone).
In fact, a major part of the testosterone inhibitory action is its conversion by Aromatase to Estradiol in the hypothalamus.
Estradiol, through the activation of its ERα receptor, reduces the frequency of GnRH pulses via probably an indirect action on kisspeptin neurons and exerts a direct inhibitory effect on pituitary gonadotropic cells. Both actions contribute to a decrease in the amplitude of LH pulses in humans.In Hypogonadotropic hypogonadism (HGHG), there is a decrease in GnRH secretion that will induce a decrease in the secretion of FSH and LH and consequently a decrease in the production of testosterone and spermatozoa.
How to stimulate spermatogenesis?
The first test to be asked is a spermogram with spermocytogram to see if it spontaneously produces spermatozoa. Expected results are usually cryptozoospermia (occasional sperm in semen) or azoospermia (no sperm in semen), at best severe oligozoospermia (low concentration of sperm in semen).The most commonly used treatment is the use of hCG (human chorionic gonadotropin) in intramuscular injection and recombinant FSH by subcutaneous injections.
HCG and LH have close molecular conformations.
The hCG has the ability to mimic the action of LH and has the advantage of having a half-life much longer than LH, which reduces the frequency of injections. hCG acts on Leydig cells to secrete intratesticular testosterone and initiate spermatogenesis,recombinant FSH (rFSH or also known as hMG) will act on Sertoli cells and seminiferous tubules to boost sperm production.
Clomiphene citrate – This anti-estrogen treatment exerts a competitive effect on the ERα receptor of the pituitary and hypothalamus, which limits the negative feedback of estradiol on the hypothalamic-pituitary complex. The pituitary gland therefore increases the secretion of gonadotropins FSH and LH, which results in an increase in testicular testosterone production and spermatogenesis.
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"When you feel like giving up, remember why you started in the first place" -
As said above, I had excruciating pain in my knee trying to leg press or squat. Especially when trying to push out of the bottom position.
Turned out to be tight hip flexors causing knee tendon to be lengthened.
Couch stretch and some lacross ball work in the hip flexor fixed it for me.
Lucky to have a physio as a friend who actually bothers to take the time to root cause my injuries.
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"When you feel like giving up, remember why you started in the first place" -
Prolactin is too low and there are some recent studies showing that low prolactin can cause sexual dystfunction but the mechanism is poorly understood.
The hCG may be causing your gyno to flair due to indrect estrogen elevation from aromatisation.
Your free testosterone is quite high and may be indirectly due to the hCG.I would suspect your anciliiaries are fake especially if the nolva is failing to calm it down.
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"When you feel like giving up, remember why you started in the first place" -
Covered with these panels
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"When you feel like giving up, remember why you started in the first place" -
Your DHEA is a little low – I would consult an endocrinologist as you might be suffering with hypopituitarism where the pituitary gland is not producing normal amounts of its hormones or you are suffering from low aromatisation due to the low testosterone level as you need a higher E2 value for libido.
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"When you feel like giving up, remember why you started in the first place" -
Could be a number of things:
1. You are overtrained if resting HR is elevated and you feel anxious waking up.
2. You are not converting the 5-HTP to Serotonin and then to Melatonin even though you are taking B5.
3. The increase in androgens, and not being cleared by COMT causing cathecholaines to not breakdown.But I’d be leaning towards 1. Check morning HR if its above 80 after sleeping then you are on the verge of CNS fatigue.
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"When you feel like giving up, remember why you started in the first place"