DrDeanStMart
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This is the only time I’m going to post this on fertility so all future questions will be redirected here.
Below are the all the articles related to hCG/hMG therapies in hypogonadism males.
IN THEORY, the best protocol is 1500-2000 I.U hCG combined with 75 I.U hMG in conjuction with an Aromatase Inhibitor followed by SERM treatment.
https://www.ncbi.nlm.nih.gov/pubmed/6430049
https://www.ncbi.nlm.nih.gov/pubmed/3142911
https://www.ncbi.nlm.nih.gov/pubmed/3928676
https://www.ncbi.nlm.nih.gov/pubmed/27475410
https://www.ncbi.nlm.nih.gov/pubmed/19838805
Excellent article on Spermatogenesis – use Google Chrome to translate from French.
https://www.sciencedirect.com/science/article/pii/S1297958916301588?via%3DihubHGHG (hypogonadotropic hypogonadism)
GnRH (Gonadotropin-releasing hormone) acts on the pituitary gland, which will secrete FSH and LH gonadotropins that are released into the bloodstream.LH acts on Leydig cells to stimulate testosterone production. Part of the testosterone will act intratesticularly on Sertoli cells to initiate spermatogenesis.
FSH works together with intratesticular testosterone in Sertoli cells of seminiferous tubules to enhance spermatogenesis. The Sertoli cell also independently secretes inhibin B.
Several mechanisms make it possible to regulate the hypothalamic-pituitary-testicular axis:
1. Inhibin B produced by Sertoli cells regulates the pituitary secretion of FSH by negative feedback. It has no direct effect on the hypothalamus.2. Increase in circulating testosterone will inhibit the secretion of GnRH and gonadotropins. In fact, a major part of the testosterone inhibitory action is its conversion by aromatase to estradiol in the hypothalamus. Estradiol, through the activation of its ERα receptor, reduces the frequency of GnRH pulses via probably an indirect action on kisspeptin neurons and exerts a direct inhibitory effect on pituitary gonadotropic cells. Both actions contribute to a decrease in the amplitude of LH pulses in humans.
3. Leptin also intervenes at the axis by activating its LEPR receptor on kisspeptin neurons [8] ;
4. Prolactin has an anti-gonotropic effect at the hypothalamic level. The mechanism of action would be at the level of the kisspeptin neuron but is still uncertain.
In HGHG, there is a decrease in GnRH secretion that will induce a decrease in the secretion of FSH and LH and consequently a decrease in the production of testosterone and spermatozoa.
How to stimulate spermatogenesis?
When a patient has a paternity project, the first test to be asked is a spermogram with spermocytogram to see if it spontaneously produces spermatozoa. Expected results are usually cryptozoospermia (occasional sperm in semen) or azoospermia (no sperm in semen), at best severe oligozoospermia (low concentration of sperm in semen.The most commonly used treatment is the use of hCG (human chorionic gonadotropin) in intramuscular injection and urinary or recombinant FSH by subcutaneous injections.
HCG and LH have close molecular conformations. The hCG has the ability to mimic the action of LH and has the advantage of having a half-life much longer than LH, which reduces the frequency of injections. HCG acts on Leydig cells to secrete intratesticular testosterone and initiate spermatogenesis,
rFSH (hMG) will act on Sertoli cells and seminiferous tubules to boost sperm production.
Clomiphene citrate has long been used empirically before the advent of the ICSI technique because of its relatively good clinical tolerance, ease of administration, and low cost. This anti-estrogen treatment exerts a competitive effect on the ERα receptor of the pituitary and hypothalamus, which limits the negative feedback of estradiol on the hypothalamic-pituitary complex. The pituitary gland therefore increases the secretion of gonadotropins FSH and LH, which results in an increase in testicular testosterone production and spermatogenesis.
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"When you feel like giving up, remember why you started in the first place" -
Local law dictates but oral medicine is fine as you can always place in another container.
Prefilled syringe is probably best but can always take week dose before travelling.
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Take on an empty stomach 30 minutes before Meal 1. The fat from the omegas will help absorption of fat soluble vitamins.
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Estradiol E2 is not the only form of estrogen metabolite in the body.
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"When you feel like giving up, remember why you started in the first place" -
Rotties you just contradicted yourself saying it has nothing to do with E2 but when hormones rise and fall…..E2 is one of those rising and falling hormones. ….
My point was that exactly. You get acne from your homrones rising and falling. That’s the root cause. The better solution would be to keep hormone levels steady and you wouldn’t get acne……
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Lack of deep sleep
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There’s plenty of research there regarding hCG and hMG protocols on fertility
The main thing is it is genetic and secondly whether complete HPTA signalling is destroyed making it extremely difficult for spermatogenesis to occur without exogenous aid.
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"When you feel like giving up, remember why you started in the first place" -
Is it high E2?
Is it high DHT?
Is it an opportunistic yeast?
Is it poor hygiene?
Is it a Vit B5 / Retinal Palmitate deficiency?
Is it that your liver metabolism is slow and inflamed?These are questions that need to be considered……not let’s blast this away with another drug……
Getting tired of this bullshit of addressing symptoms rather than figuring out what the fck has gone wrong in your body……
You didn’t have acne…..now you have……so there’s obviously a root cause…….
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"When you feel like giving up, remember why you started in the first place" -
There’s probably a lot more sides to a course of antibiotics than roaccutane…….
However, addressing the root cause of why the acne has occurred is more important than annihilation by a drug……..
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"When you feel like giving up, remember why you started in the first place" -
So yesterday and today had adjustments done after resting a second week on Conn’s advice but he finally gave the go ahead to get back to light training as he was surprised how well my neck is responding.
We’re now up to 15 minutes of traction work whereby a metal bar brace is secured into the back of my neck and tightened to force new posture. It takes 20 minutes for propioception to really adapt to a change so we’re getting close.
Looking forward to the difference in the next w weeks as that’s now 5 of the 12 treatments done.Yesterday done a light upper body superset workout to get a feel for the movement patterns and found no issue so time to build on it properly over the next week.
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"When you feel like giving up, remember why you started in the first place" -
Yes but please guys remember possession is legal. Importing is not so keep that in mind.
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"When you feel like giving up, remember why you started in the first place" -
Could be E1……..
E2 isn’t always the culprit…….
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There are a few plus if you know some postgrads with access to HPLC it’s easy.
The own fall of most labs is profit……cutting corners etc. but they’re are some very reputable at the moment where I know the guys will not cut corners……
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"When you feel like giving up, remember why you started in the first place" -
As I said in my training log, my count was zero…..I will detail what I shall be doing once I return from my honeymoon in March…….
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"When you feel like giving up, remember why you started in the first place" -
Ok I will put this simply……
Anavar DOES suppress LH and DOES SUPPRESS YOUR HPTA.
https://www.ncbi.nlm.nih.gov/pubmed/8319371
However, you MAY be more genetically susceptible to faster recovery POST cycle; hence MILDER suppression….BUT SUPPRESSION NONETHELESS.
Even still, an anavar only oral cycle is NOT going to yield any appreciable muscle mass……….
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"When you feel like giving up, remember why you started in the first place"