[abdou]

Thank you sirrr ❤ so i lower the carb and in the contest day i increase it right ? Second question what is the point with fat ? I see bodybuilders Who take fat even in the final day

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[abdou]

Welcome sir, any tips for the peak week for a natural athlete ?

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[abdou]

James did your diet change a lot with aceto ?

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[abdou]

thank you

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[abdou]

oatmeal, potato , rice ( dry measurements)
steak ( cooked)

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[abdou]

thank you guys

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[abdou]

This is long to explain…..

Lets take Enanthate for example:
Having an average half life of 6-7 days, once could do biweekly but it would still yield a small interdose peak and trough although not as severe as single frequency. The peaks and troughs will feed into aromatase activity etc.

Any compound or ester, ED dosing will ensure completely stable plasma levels as the drug is being administered and absorbed into the system at the same rate every day.

Pharmacokinetics and Pharmacodynamics of Nandrolone Esters in Oil Vehicle: Effects of Ester, Injection Site and Injection Volume
http://jpet.aspetjournals.org/content/281/1/93.long

This study compared the pharmacokinetics and pharmacodynamics of two currently available esters of nandrolone, the decanoate and phenylpropionate, as well as the influence of i.m. injection sites (gluteal vs. deltoid) and injection volumes (4 mlvs. 1 ml).

We analyzed these data using an indirect pharmacodynamic response model, which has demonstrated, for the first time, prominent pharmacological differences between esters differing in only a single carbon in the side-chain, as well as systematic differences attributable to injection site and volume in humans.

The type of ester influenced the absorption profile of nandrolone:
Phenylpropionate ester was best described by a one-compartment absorption model and the
Decanoate ester was best described by a two-compartment absorption model.
**I discussed one compartment models on the MuscleMentors Podcast****

The total dose of the phenylpropionate ester is administered into the “fast” compartment characterized by the rapid absorption rate constant.

Only ∼14% of the total dose of the decanoate ester is administered into this “fast” compartment, with the remaining ∼86% of the total dose being administered into the “slow” compartment characterized by a slower absorption rate constant.

In addition, the rate of absorption from the fast compartment was greater for the deltoid muscle than the gluteal muscle.
**Injection site will make a difference to absorption**

Variations in side-chain ester chemistry are important in the pharmacokinetics of androgen esters in oil vehicle (Behre et al., 1990).

Experimental studies suggest that absorption rates are predicted by the oil/water partition coefficients (or hydrophobicity) and that the oil vehicle is absorbed more slowly than the androgen ester (Tanaka et al., 1974).

In humans, the very short propionate (three-carbon aliphatic) ester of testosterone has distinctly shorter duration of action than esters with longer (seven- or eight-carbon) side-chains (Nieschlag et al., 1976;Schulte-Beerbuhl and Nieschlag, 1980; Schurmeyer and Nieschlag, 1984;Belkien et al., 1985; Fujioka et al., 1986).

More subtle changes in side-chain ester structure have proven ineffective in altering human clinical pharmacokinetics, because substitution of a linear aliphatic side-chain of seven carbons (enanthate) with either a saturated, cyclized, seven-carbon aliphatic chain (cyclohexanecarboxylate) (Schurmeyer and Nieschlag, 1984) or a linear, aliphatic, eight-carbon chain (cypionate) (Schulte-Beerbuhl and Nieschlag, 1980) resulted in virtually unchanged kinetics.
**However, inter individuality with regard to sterics of the esters may be imporant with how PDE7B cleaves the esters**

Wider variation in ester side-chain chemistry to include greater chain length and/or aromatic ring structures is a more effective determinant of ester pharmacokinetics, because nandrolone hexoxyphenylpropionate ester (aromatic ring with 18 carbons) had far better depot properties, with a prolonged and retarded release profile, compared with the decanoate (aliphatic chain with 10 carbons) (Belkien et al., 1985).
**More obvious as longer chain will be more hydrophobic**

The present study indicates that a side-chain ester consisting of a 10-carbon aliphatic chain has better depot properties than a nine-carbon chain including an aromatic ring.
**Again aliphatic nature versus sterics on the ester**

Because the vehicle (arachis oil) was unchanged during this study and because of the experimental observation that the oil vehicle influences local reaction to the oil injection (Brown et al., 1944), as well as androgen ester pharmacology (Ballard, 1980; Al-Hindawi et al., 1986), the present conclusions may be extrapolated to other vegetable oil injection vehicles only with caution.

Injection technique, including injection site, volume and concentration, as well as the nature of the vehicle, could theoretically be important for androgen ester release rate.
**But also for downstream effects of aromatase interaction following absoprtion; slower absorption or steadier absorption may be favourable**

Injection site may be important because of differences in tissue composition (Cockshott et al., 1982) and blood flow (Bederka et al., 1971); indeed, i.m. oil-based injections may more accurately be termed intermuscular (Ballard, 1968) or intralipomatous (Cockshottet al., 1982).

The former reflects the tendency of oil vehicle to distribute along intermuscular fascial planes (Ballard, 1968), whereas the latter depends upon the amount of fat at the injection site (including systematic gender differences) (Moddermanet al., 1983) together with needle geometry and anatomy of the injection depot.

Intralipomatous deposition of injections with a larger vehicle volume may explain the slower release kinetics of nandrolone decanoate in the gluteal region, as well as the differences from the deltoid site, which has a lower fat content.

The higher blood flow in the deltoid, compared with the gluteal, muscle (Evans et al., 1975) may also be important.

Analogous site-dependent differences in absorption rate and physiological effects have been described for a variety of drugs in aqueous solution (Greenblatt and Koch-Weser, 1976).

To our knowledge, there are no previous reports examining the systemic pharmacokinetic and pharmacodynamic effects of injection site and volume for androgen esters in oil vehicle in men.

Thank you sir , you are the boss

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[abdou]

@abdou hi

Very good question, absolutely it is far better to administer daily imo split into smaller shots. Personally I can get away with far less ai use and I feel like daily administration will put less stress on your body, less scar tissue and for me certainly feels like lower dose works better.

@drdeanstmart can elaborate on pharmacology side of things he can explain this far better than me

Thanks a lot bro and good luck ❤

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[abdou]

Rebound cycle:
350 prop. 0.5 ml daily
350 eq 0.5
300 tren .45
300 mast .45
700 primo 1
12.5 aromasin 1/2 per bed
25 mcg t3 50mcg t4 AM

6 iu gh training day

Current PED set up during rebound phase

Actually feel great on this, very fresh and healthy. Will run some bloods next week then again in 12 weeks

Any benefits for the daily mini dose over 2-3 shots per week ?

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[abdou]

@luke sandoe thank you si blast and cruise are bad for fertility, i was running a mild cycle for a 8 weeks now and i want To lower the doses for 4 weeks then raise it again , i have a contest in april

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[abdou]

@luke sandoe, whats better doing a cycle then pct then cycle again or blast and cruise ?

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